Dr. Isabelle Zink

Room 3.030
1030 Wien, Djerassiplatz 1
T: +43-4277-
E: Isabelle.zink@univie.ac.at

Google Scholar

cv and list of publications


Research focus

I study the molecular function, cellular roles, and interactions of immune systems like CRISPR-Cas and Argonautes in Archaea, focusing on both their virus defense mechanisms and broader roles beyond immunity. Additionally, I repurpose these systems as tools for genetic engineering in Archaea. As a researcher, I value a comprehensive approach, combining in vivo and in vitro work to fully understand these systems.


Ongoing project


Curriculum Vitae

Education

01/2020   Ph.D. (pass with distinction) in Biology, University of Vienna, Austria
11/2013
Diploma Magistra reis naturalis (M.Sc. equivalent) in Microbiology and Genetics, University of Vienna, Austria
07/2009  1st Diploma (B.Sc. equivalent) in Biology at the University of Vienna, Austria

  

 

Research and Professional Experience

06/2024 - present
Postdoctoral researcherat the Dep. of Functional and Evolutionary Ecology, Archaea Biology and Ecogenomics Unit, University of Vienna, Austria.
04/2021 - 06-2024

Postdoctoral researcher at the Laboratory of Microbiology, Wageningen University, The Netherlands, Prof. Dr. John van der Oost group, Project: "Nuclease engineering, CRISPR-Cas and Argonautes".

01/2020 - 04/2021

Postdoctoral researcher at the Dep. of Functional and Evolutionary Ecology, University of Vienna, Austria, Prof. Christa Schleper group, Project: "RNA interference by the type III CRISPR-Cas system in Saccharolobis solfataricus"

03/2014 - 01/2020

Ph.D. student at the Dep. of Functional and Evolutionary Ecology, University of Vienna, Austria, Advisor: Prof. Christa Schleper. Ph.D. thesis: "Investigation of CRISPR-mediated RNA interference in the hyperthermophylic Archaeon Sulfolobus solfataricus"
10/2017Co-organiser of the international CRISPR sypmosium: "Editing genomes with CRISPR: Between scientific breakthroughs and social challenges", Vienna, Austria. (see: rri.univie.ac.at/workshops-events/crispr-symposium/)
05-08/2014Guest researcher during Ph.D. studies at the Institute of Genome Biology, Illinois, USA, Host: Prof. Rachel Whitaker group.
03 2012 - 11/2013

Diploma student (M.Sc. equivalent) at the Dep. of Functional and Evolutionary Ecology, University of Vienna, Austria, Prof. Dr. Christa Schleper group. Diploma thesis: "Development of a plasmid shuttle vector system for CRISPR studies in the archaeon Sulfolobus solfataricus"

 

 

Grants and Fellowships

2022 - 2025  Schroedinger Postdoctoral fellowship (FWF Autsrian Science fund) for performing 2 years of research at the Wageningen University, The Netherlands, 1 year return phase to University of Vienna, Austria
2018

 

PhD Completion grant of the University of Vienna for supporting the finalization of the Ph.D. thesis (6 months funding)

2016

Microbiology Society Conference Grant 2016 for attendance of the MboA5 conference in London, UK

2016 - 2018

 

DOC fellowship – Internationally reviewed doctoral Fellowship Programme of the Austrian Academy of Sciences (ÖAW) supporting highly qualified doctoral candidates (24 months funding for Ph.D. thesis)


Publications

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Wimmer E, Zink IA, Schleper C. Reprogramming CRISPR-Mediated RNA Interference for Silencing of Essential Genes in Sulfolobales. in Methods in Molecular Biology book series (MIMB): Archaea. Band 2522. Springer. 2022. S. 177-201. (Methods in Molecular Biology). doi: 10.1007/978-1-0716-2445-6_11

Zink IA, Fouqueau T, Tarrason Risa G, Werner F, Baum B, Bläsi U et al. Comparative CRISPR type III-based knockdown of essential genes in hyperthermophilic Sulfolobales and the evasion of lethal gene silencing. RNA Biology. 2021;18(3):421-434. Epub 2020 Sep 21. doi: 10.1080/15476286.2020.1813411

Zink IA, Pfeifer K, Wimmer E, Sleytr UB, Schuster B, Schleper C. CRISPR-mediated gene silencing reveals involvement of the archaeal S-layer in cell division and virus infection. Nature Communications. 2019 Okt 22;10(1):4797. 4797. doi: 10.1038/s41467-019-12745-x

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