Navigating the archaeal frontier: insights and projections from bioinformatic pipelines

Autor(en)
Val Karavaeva, Maria Filipa Baltazar de Lima de Sousa
Abstrakt

Archaea continues to be one of the least investigated domains of life, and in recent years, the advent of metagenomics has led to the discovery of many new lineages at the phylum level. For the majority, only automatic genomic annotations can provide information regarding their metabolic potential and role in the environment. Here, genomic data from 2,978 archaeal genomes was used to perform automatic annotations using bioinformatics tools, alongside synteny analysis. These automatic classifications were done to assess how good these different tools perform in relation to archaeal data. Our study revealed that even with lowered cutoffs, several functional models do not capture the recently discovered archaeal diversity. Moreover, our investigation revealed that a significant portion of archaeal genomes, approximately 42%, remain uncharacterized. In comparison, within 3,235 bacterial genomes, a diverse range of unclassified proteins is obtained, with well-studied organisms like Escherichia coli having a substantially lower proportion of uncharacterized regions, ranging from

Organisation(en)
Department für Funktionelle und Evolutionäre Ökologie
Journal
Frontiers in Microbiology
Band
15
ISSN
1664-302X
DOI
https://doi.org/10.3389/fmicb.2024.1433224
Publikationsdatum
09-2024
Peer-reviewed
Ja
ÖFOS 2012
106022 Mikrobiologie
Schlagwörter
ASJC Scopus Sachgebiete
Microbiology (medical), Microbiology
Link zum Portal
https://ucrisportal.univie.ac.at/de/publications/cd1ccf03-70b5-436e-bdd9-eacfbfe2b9fc