Navigating the archaeal frontier: insights and projections from bioinformatic pipelines
- Autor(en)
- Val Karavaeva, Maria Filipa Baltazar de Lima de Sousa
- Abstrakt
Archaea continues to be one of the least investigated domains of life, and in recent years, the advent of metagenomics has led to the discovery of many new lineages at the phylum level. For the majority, only automatic genomic annotations can provide information regarding their metabolic potential and role in the environment. Here, genomic data from 2,978 archaeal genomes was used to perform automatic annotations using bioinformatics tools, alongside synteny analysis. These automatic classifications were done to assess how good these different tools perform in relation to archaeal data. Our study revealed that even with lowered cutoffs, several functional models do not capture the recently discovered archaeal diversity. Moreover, our investigation revealed that a significant portion of archaeal genomes, approximately 42%, remain uncharacterized. In comparison, within 3,235 bacterial genomes, a diverse range of unclassified proteins is obtained, with well-studied organisms like Escherichia coli having a substantially lower proportion of uncharacterized regions, ranging from
- Organisation(en)
- Department für Funktionelle und Evolutionäre Ökologie
- Journal
- Frontiers in Microbiology
- Band
- 15
- ISSN
- 1664-302X
- DOI
- https://doi.org/10.3389/fmicb.2024.1433224
- Publikationsdatum
- 09-2024
- Peer-reviewed
- Ja
- ÖFOS 2012
- 106022 Mikrobiologie
- Schlagwörter
- ASJC Scopus Sachgebiete
- Microbiology (medical), Microbiology
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/cd1ccf03-70b5-436e-bdd9-eacfbfe2b9fc