Navigating the archaeal frontier: insights and projections from bioinformatic pipelines

Autor(en)

Val Karavaeva, Maria Filipa Baltazar de Lima de Sousa

Abstrakt

Archaea continues to be one of the least investigated domains of life, and in recent years, the advent of metagenomics has led to the discovery of many new lineages at the phylum level. For the majority, only automatic genomic annotations can provide information regarding their metabolic potential and role in the environment. Here, genomic data from 2,978 archaeal genomes was used to perform automatic annotations using bioinformatics tools, alongside synteny analysis. These automatic classifications were done to assess how good these different tools perform in relation to archaeal data. Our study revealed that even with lowered cutoffs, several functional models do not capture the recently discovered archaeal diversity. Moreover, our investigation revealed that a significant portion of archaeal genomes, approximately 42%, remain uncharacterized. In comparison, within 3,235 bacterial genomes, a diverse range of unclassified proteins is obtained, with well-studied organisms like Escherichia coli having a substantially lower proportion of uncharacterized regions, ranging from

Organisation(en)

Department für Funktionelle und Evolutionäre Ökologie

Journal

Frontiers in Microbiology

Band

15

ISSN

1664-302X

DOI

https://doi.org/10.3389/fmicb.2024.1433224

Publikationsdatum

09-2024

Peer-reviewed

Ja

ÖFOS 2012

106022 Mikrobiologie

Schlagwörter

ASJC Scopus Sachgebiete

Microbiology (medical), Microbiology

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/navigating-the-archaeal-frontier-insights-and-projections-from-bioinformatic-pipelines(cd1ccf03-70b5-436e-bdd9-eacfbfe2b9fc).html