Modular structure of complex II

Autor(en)

Valeriya Karavaeva, Maria Filipa Baltazar de Lima de Sousa

Abstrakt

Succinate dehydrogenases (SDHs) and fumarate reductases (FRDs) catalyse the interconversion of succinate and fumarate, a reaction highly conserved in all domains of life. The current classification of SDH/FRDs is based on the structure of the membrane anchor subunits and their cofactors. It is, however, unknown whether this classification would hold in the context of evolution. In this work, a large-scale comparative genomic analysis of complex II addresses the questions of its taxonomic distribution and phylogeny. Our findings report that for types C, D, and F, structural classification and phylogeny go hand in hand, while for types A, B and E the situation is more complex, highlighting the possibility for their classification into subgroups. Based on these findings, we proposed a revised version of the evolutionary scenario for these enzymes in which a primordial soluble module, corresponding to the cytoplasmatic subunits, would give rise to the current diversity via several independent membrane anchor attachment events.

Organisation(en)

Department für Funktionelle und Evolutionäre Ökologie

Journal

Biochimica et Biophysica Acta - Bioenergetics

Band

1864

Seiten

148916

Anzahl der Seiten

17

ISSN

0005-2728

DOI

https://doi.org/10.1016/j.bbabio.2022.148916

Publikationsdatum

09-2022

Peer-reviewed

Ja

ÖFOS 2012

106014 Genomik

Schlagwörter

ASJC Scopus Sachgebiete

Biophysics, Biochemistry, Cell Biology

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/modular-structure-of-complex-ii(180f34b1-0998-4ef1-89e2-a0817faa377f).html