Nematode-bacterium symbioses-cooperation and conflict revealed in the "omics" age

Autor(en)
Kristen E Murfin, Adler R Dillman, Jeremy M Foster, Silvia Bulgheresi, Barton E Slatko, Paul W Sternberg, Heidi Goodrich-Blair
Abstrakt

Nematodes are ubiquitous organisms that have a significant global impact on ecosystems, economies, agriculture, and human health. The applied importance of nematodes and the experimental tractability of many species have promoted their use as models in various research areas, including developmental biology, evolutionary biology, ecology, and animal-bacterium interactions. Nematodes are particularly well suited for the investigation of host associations with bacteria because all nematodes have interacted with bacteria during their evolutionary history and engage in a variety of association types. Interactions between nematodes and bacteria can be positive (mutualistic) or negative (pathogenic/parasitic) and may be transient or stably maintained (symbiotic). Furthermore, since many mechanistic aspects of nematode-bacterium interactions are conserved, their study can provide broader insights into other types of associations, including those relevant to human diseases. Recently, genome-scale studies have been applied to diverse nematode-bacterial interactions and have helped reveal mechanisms of communication and exchange between the associated partners. In addition to providing specific information about the system under investigation, these studies also have helped inform our understanding of genome evolution, mutualism, and innate immunity. In this review we discuss the importance and diversity of nematodes, "omics"' studies in nematode-bacterial systems, and the wider implications of the findings.

Organisation(en)
Department für Mikrobiologie und Ökosystemforschung, Department für Limnologie und Bio-Ozeanographie, Department für Ökogenomik und Systembiologie
Journal
Biological Bulletin
Band
223
Seiten
85-102
ISSN
0006-3185
Publikationsdatum
2012
Publikationsstatus
Veröffentlicht
Peer-reviewed
Ja
ÖFOS 2012
106014 Genomik, 106022 Mikrobiologie
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/nematodebacterium-symbiosescooperation-and-conflict-revealed-in-the-omics-age(14915197-d431-4357-aa56-963b68884fd6).html