Congratulations to Filipa Sousa for her contribution to the new publication in Protein Science:
Characterization of DsrD and its interaction with the DsrAB dissimilatory sulfite reductase
Microbial dissimilatory sulfate reduction involves the reduction of sulfate to sulfite and further to a DsrC-trisulfide by DsrAB, with DsrD acting as an allosteric activator, enhancing sulfite reduction. This study revealed three DsrD groups in organisms with reductive-type DsrAB. In vitro and in silico analyses identified the conserved β-loop of DsrD as essential for its interaction with DsrAB and its activity-promoting effect, further elucidating its mechanism of action.
Original article:
Barbosa ACC, Venceslau SS, Ferreira D, Neukirchen S, Sousa FL, Melo MN, Pereira IAC. Characterization of DsrD and its interaction with the DsrAB dissimilatory sulfite reductase. Protein Sci. 2024 Dec;33(12):e5222. doi: 10.1002/pro.5222. PMID: 39548845; PMCID: PMC11568415.
