New publication in Nature Scientific Reports

24.01.2025

"A novel type of hemoglobin confers host-derived nitric oxide resistance to the opportunistic pathogen Acinetobacter baumannii"

Congratulations to Jordi Zamarreño Beas, Filipe Folgosa, Val Karavaeva, Filipa L. Sousa & Lígia M. Saraiva on their new publication in Nature Scientific Reports:

 

A novel type of hemoglobin confers host-derived nitric oxide resistance to the opportunistic pathogen Acinetobacter baumannii

This study reports the discovery of a new type of globin in the multidrug-resistant Acinetobacter baumannii. Bacterial (hemo)globins play a key role in nitric oxide detoxification, a crucial process that helps pathogens evade the immune system. Understanding bacterial stress adaptation mechanisms is essential for developing new strategies to combat multidrug-resistant bacteria.

 

Original article:

Beas, J. Z., Folgosa, F., Karavaeva, V., Sousa, F. L., & Saraiva, L. M. (2025). A novel type of hemoglobin confers host-derived nitric oxide resistance to the opportunistic pathogen Acinetobacter baumannii. Scientific Reports, 15(1), 5969.

DOI: https://doi.org/10.1038/s41598-025-88123-z

© Zamarreno et al. (Fig. 7) A. baumannii hemoglobin structural model and its comparison with flavohemoglobin, single domain and truncated globins.