New publication in Nature Communications

03.06.2025

"Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon"

Congratulations to Nika Pende on co-authoring the new article in Nature Communications:

 

"Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon"

In this study, we characterized the extracellular vesicles (EVs) produced by the human gut-associated archaeon Methanobrevibacter smithii. Cryo-electron tomography revealed that the EVs form by budding from the membrane and are released through the peptidoglycan layer. These EVs are enriched in histones, DNA repair proteins, and extrachromosomal circular DNA (eccDNA), which is linked to methanogenesis, suggesting a potential role in regulating methane production in the human gut.

 

Red the full article here: Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon | Nature Communications

 

Original paper:

Baquero, D.P., Borrel, G., Gazi, A. et al. Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon. Nat Commun 16, 5093 (2025). doi.org/10.1038/s41467-025-60272-9

© Baquero, D.P., Borrel, G., Gazi, A. et al. A: Tomographic reconstruction of an M. smithii cell producing EVs. [...] B: A schematic representation of EVs biogenesis and release by an M. smithii cell. [...]

Nika Pende