Yersinia pestis Interacts With SIGNR1 (CD209b) for Promoting Host Dissemination and Infection

Autor(en)

Kun Yang, Yingxia He, Chae Gyu Park, Young Sun Kang, Pei Zhang, Yanping Han, Yujun Cui, Silvia Bulgheresi, Andrey P Anisimov, Svetlana V Dentovskaya, Xiaoling Ying, Lingyu Jiang, Honghui Ding, Olivia Adhiambo Njiri, Shusheng Zhang, Guoxing Zheng, Lianxu Xia, Biao Kan, Xin Wang, Huaiqi Jing, Meiying Yan, Wei Li, Yuanzhi Wang, Xiding Xiamu, Gang Chen, Ding Ma, Sara Schesser Bartra, Gregory V Plano, John D Klena, Ruifu Yang, Mikael Skurnik, Tie Chen

Abstrakt

Yersinia pestis, a Gram-negative bacterium and the etiologic agent of plague, has evolved from Yersinia pseudotuberculosis, a cause of a mild enteric disease. However, the molecular and biological mechanisms of how Y. pseudotuberculosis evolved to such a remarkably virulent pathogen, Y. pestis, are not clear. The ability to initiate a rapid bacterial dissemination is a characteristic hallmark of Y. pestis infection. A distinguishing characteristic between the two Yersinia species is that Y. pseudotuberculosis strains possess an O-antigen of lipopolysaccharide (LPS) while Y. pestis has lost the O-antigen during evolution and therefore exposes its core LPS. In this study, we showed that Y. pestis utilizes its core LPS to interact with SIGNR1 (CD209b), a C-type lectin receptor on antigen presenting cells (APCs), leading to bacterial dissemination to lymph nodes, spleen and liver, and the initiation of a systemic infection. We therefore propose that the loss of O-antigen represents a critical step in the evolution of Y. pseudotuberculosis into Y. pestis in terms of hijacking APCs, promoting bacterial dissemination and causing the plague.

Organisation(en)

Externe Organisation(en)

Huazhong University of Science and Technology, Shihezi University, Korea University, University of Illinois at Chicago, Beijing Institute of Microbiology and Epidemiology, State Research Center for Applied Microbiology and Biotechnology (SRCAMB), Chuka University, Chinese Center for Disease Control & Prevention, University of Miami, University of Canterbury, University of Helsinki

Journal

Frontiers in Immunology

Band

10

Anzahl der Seiten

15

ISSN

1664-3224

DOI

https://doi.org/10.3389/fimmu.2019.00096

Publikationsdatum

2019

Peer-reviewed

Ja

ÖFOS 2012

106023 Molekularbiologie

Schlagwörter

ASJC Scopus Sachgebiete

Immunology and Allergy, Immunology

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/yersinia-pestis-interacts-with-signr1-cd209b-for-promoting-host-dissemination-and-infection(2c3adf81-9986-4437-b3bc-f05f56861e0b).html